As part of the range, we wanted an anti-ageing serum that addresses the many triggers associated with cellular ageing:
Peptides in the treatment of ageing: Peptides are the fundamental building blocks of your skin, helping lift and define facial contours. Melittin Peptide (Bee Venom) is a vital signal protein that causes a rush of blood to the area, thus controlling the muscle contractions in your face by tricking the skin into thinking it has been lightly stung, revitalising the collagen and elastin proteins.
Niacinamide: Working as an aesthetician for over 25 years, I have witnessed Niacinamide’s (Vitamin B3) affinity with the skin. Not only does it ward off signs of premature ageing, but it is also very balancing, clearing congested pores whilst regulating the flow of sebum, making it ideal for oily skin, prone to breakouts.
The treatment of ageing: A precursor for co-factors NAD(H)and NADP(H), essential in various cellular pathways affecting skin physiology. NADH and NADPH decrease with age; therefore, supplementing your skin with Niacinamide provides unique anti-ageing benefits. One of these benefits is that it enhances barrier function. NADPH is a cofactor for synthesising Lipids, including Ceramides and Fatty acids, crucial for barrier function. A compromised barrier function is prevalent in ageing skin and can contribute to heightened sensitivity and irritation by allowing external insults to enter your skin quickly. Several studies have demonstrated that regular application of topical Niacinamide reduces skin sensitivity to irritating ingredients and helps to improve the tolerability of elements such as Retinoids. In addition, Niacinamide increases the production of the proteins keratin, involucrin, and filaggrin – essential factors in forming and maintaining the cornified, outermost layer of the skin.
Niacinamide also reduces expression lines after prolonged use; a 12-week study of topical 5% niacinamide cream demonstrated a 21% improvement in expression lines and 14% clarity in skin tone. In vitro studies also suggest that Niacinamide increases dermal collagen production whilst also reducing excess dermal glycosaminoglycan production. Hence, skin is more supple and as little as 4%, Niacinamide used over three months can significantly improve hyperpigmentation.
The treatment of oily acne prone: Niacinamide reduces sebum production, making it a valuable ingredient for those who desire skin rejuvenation but may be acne-prone. The anti-inflammatory properties are primarily for those with papules and pustules; clinically, it has been found to improve skin texture and reduce pore size, protecting pores from stretching further when exposed to damaging UV light.
The treatment of hyperpigmentation: This is also the product for you for those concerned with sun damage, melasma or PIH. In vivo studies have demonstrated the effectiveness of Niacinamide at preventing and reducing pigmentation. One study found that as little as 5% Niacinamide contained seasonal-induced increases in pigmentation (when UV levels are at their strongest) when used twice daily for 12 weeks. Another study found that 2% Niacinamide increased skin lightening in as little as four weeks. In vitro studies show that Niacinamide can decrease melanosomes’ transfer from melanocytes to keratinocytes by as much as 65%, preventing pigment from leaking into the skin cells.
Some of the most extensive research around hyperpigmentation is with N-acetyl glucosamine’s (NAG) ingredients, which we have included in the formula. In a clinical study, 2% applied topically has been shown to reduce hyperpigmentation significantly. It works by inhibiting tyrosinase activation, the enzyme involved in melanin synthesis, and when combined with 4% niacinamide, the pigmentation reducing effect is even more significant. For this reason, we have synergistically combined both N-acetyl glucosamine and Niacinamide in the B+ complex.
Clients also see great results when treating hyperpigmentation when B+ is used oppositely with the C+ complex.
Repairing the barrier function: Niacinamide stimulates the synthesis of ceramides, which is significant when alleviating dry skin concerns and calming inflammatory markers. N-Acetyl Glucosamine NAG is another skin-identical ingredient that maintains the barrier and reduces dryness; it also increases moisture content and collagen production in your skin.
We are excited about the results, including improved youthful bounce and snapback. Betox brings a luminous quality to your skin, targeting dark spots whilst helping to strengthen and re-densify blemished, thin skin, reducing signs of inflammation and redness.
Use at the opposite time of day from the C+ skin shot, as they may cancel each other out.