Cosmeceutical | Ageing

8 Science Backed Anti Ageing Ingredients to Keep You Youthful

I have been living in this excellent body for over 60 years
I love it, as long as it doesn’t get too fat, or too thin or doesn’t break
I think, thank goodness
       Joanna Lumley

Youth is a gift from nature, but age is a work of art.

No more accurate word has ever been spoken.

That is if we are to embrace ageing gracefully.

But as we age, the mechanisms controlling our skin change.

Breakdowns occur in your dermal structure, leading to greater fragility and reduced healing.

As the founder of the Naked Chemist, I’m often asked what my top anti ageing ingredients are.

So, with over 30 years of experience as a medical esthetician, here’s my tried and tested verdict.


Anti Ageing Ingredients

Vitamin A

There is no question that vitamins are anti ageing and can help the appearance of your skin and Vitamin A is one of the most researched ingredients for anti-ageing.

This study (1) found rapid improvement in ageing skin, demonstrating its importance for average cell growth and function and how it can help modulate collagen synthesis.

Vitamin A derivatives are referred to as retinoids and include the following:

  • retin A
  • retinol palmitate
  • tazorac
  • the oral acne drug Accutane
  • retinyl aldehyde and retinyl palmitate

A+ Retinol skin shot is our go-to treatment containing vitamin A.

Vitamin B

Vitamin B is an important anti ageing ingredient. It is essential for normal cell functioning and helping to repair damaged skin.

Multiple clinical studies (2) show how it can provide a broad array of improvements in the appearance of ageing, such as reducing red blotchiness and stubborn age spots, especially when combined with N acetyl glucosamine.

Our B+ niacinamide skin shot, which contains vitamins B3, B5, and N acetyl glucosamine, is the perfect balancing, anti-ageing treatment.

Vitamin C

This is a powerful antioxidant that helps to prevent cellular damage from oxidation.

Vitamin C is also essential for collagen production and is an effective skin brightener. It helps to even out pigment and spots caused by UV damage.

You can find this in the C+ skin shot.

Vitamin E

Referred to as tocopherol, it is a fat-soluble vitamin that serves as a topical vitamin that is particularly useful when combined with vitamin C as an antioxidant.

It helps to repair fragile, damaged skin and ward off signs of ageing.


This study (3) found, several alterations in aged skin can contribute to a defective barrier function.

Therefore, it makes sense to replenish your barrier function with skin-identical ingredients to keep your skin healthy and ward off ageing.

Glycolipids, ceramides, fatty acids, and cholesterol are great examples of lipids in your skin that are depleted with age.

These ingredients are essential for skin health as they replenish and protect, reducing inflammation and premature ageing.

Fortify Barrier Repair cream is intelligently formulated with the correct ratio of lipids found in healthy skin.


Dehydrated skin can look dull and flaky, so as you age, your skin needs to stay hydrated to function well.

Ensure you regularly apply a topical humectant-rich formula like H20 Hydrating skin shot that contains hyaluronic acid and urea, which plump your skin, smooth rough surface texture, and improve fine lines.


Peptides in anti-ageing skincare reduce expression lines and puffiness and improve skin elasticity and texture.

These are some of the most beneficial ingredients for influencing ageing skin to behave like younger skin, so much so that we dedicated an entire article to this topic, which you can read here.

DNA age delay skin shot contains copper peptides that help reverse many conditions associated with prematurely aged skin.


These potent ingredients neutralise the destructive effects of free radicals, rendering them harmless and preventing skin impairment at a cellular level.

They also help to calm inflammation in the dermis, which can cause collagen depletion.

This study (4) found that when antioxidants are topically applied, they have a protective effect and will shield against UV rays, allowing them to repair themselves naturally, so you should use antioxidants in the morning and throughout the day.

For further reading, this article looks at the role of antioxidants and whether or not they can reverse ageing.

To Conclude. The naked truth

You don’t need to let the prospect of ageing get you down.

As you can see, there are some wonderful science-backed anti ageing skin treatments that can help to improve your skin.

Using the above ingredients in a well-thought-out skincare routine will go a long way in helping you to improve the appearance of any age-related concerns you may have.

Whilst you can get your expression lines treated with Botox or fillers, if you go overboard, you may become a distorted version of the person you are; that is not what actual skin health is all about.

You need to invest in your skin and use intelligent ingredients in a well-thought-out formula to help maintain your youthful, vibrant glow for now and many years to come.


  1. Retinoids in the treatment of skin ageing: an overview of clinical efficacy and safety
  2. Niacinamide: A B Vitamin that Improves Aging Facial Skin Appearance

  3. Ageing-associated alterations in epidermal function and their clinical significance

  4. Protective effects of topical antioxidants in humans

6 replies on “8 Science Backed Anti Ageing Ingredients to Keep You Youthful”

Hi. I enjoy your articles and believe your products must be good too! I would like to change my skincare routine as I have never had dry skin/perioral dermititis as I have this fall/winter. I am 45 fair skin & hair. Hormonal blemish and dry skin a couple days monthly. Using tretoinin .1 for a few years, good results. Am: Cetaphil- hylaronic acid-argon oil-cerave then IT cos. CC as foundation. Pm: Cetaphil- tretoinin-argon-cerave and I’ve been using otc fungal cream on my chin near lips for pd. I think I need more than just argon oil and include a cream that will be more moisturizing at night. I can’t do a lot of layers though. If it’s too heavy or any fragrance I can’t leave it on. What do you think? Thanks for advice.

Hi Christine
Thank you for your feedback I really appreciate it it’s rewarding when people like yourself glean some knowledge that will help return their skin back to health. Christine it sounds like you have a nice little routine going on and if your skin can withstand tretoinin great, although would switch it out to use at night and H20 in the morning and maybe at some point introduce vitamin c to your regime also to help prevent premature ageing further – just be careful not to over sensitise your skin…

I would say listen to your skin-it sounds like you do a pretty good job of this. If you are looking for real moisture relief I love Savior, it’s calming healing very good for a lipid dry skin. Fortify is about repairing the barrier and putting back what is depleted and missing with both are great, if you don;t want a cream base then bio lipid is the hero product here..none of my formulas are heavy and none have fragrance of any type. Miracle cleanse might be a good bet also and retinol night oil is gorgeous, modeled on sunday riley but without the price tag-although it sounds like you have this covered with the treitinoin. Don;t forget to use your essential fatty acids to mositurise from within….I hope this helps. samantha

I need an advice please.
Firstly I’m 34 and I have been on Tretinoin 0.5 and then 0.1 gel for 6 moths. I have read some great and some horror stories about this Ingredient. At 1st my skin like 95% of people using it, went through purging, scaling, peeling, irritating period.
However on the 3-4 month I started to notice small pitted acne like scars starting to form on my left cheek. They appear to look like large connected together pores. Something which I never had in that place before. I decided to continue using Tretinoin as I was hoping that what Tretinoin’caused’ that Tretinoin is going to fix/remove. Now I have been on in for 6 moths now and The scars are still there. I don’t know why did I get them? If Tretinoin has uncovered previously unseen scars?
I love the way the tretinoin evened out my skin tone, faded sun spots, and made my skin look overall more healthy, but I don’t want indented acne scars either.
But if VIT A is causing extreme exfoliation surely by now the skin should even up…and indents should even up. I read on interned that a lot of people have the same problem…
Has anyone else had this happen or know of anyone else that this has happened to. I wonder if it is just a part of the process of the tretinon doing its job and the indents will fill in eventually. My dermatologist says that tretinoin will not cause indented acne scars.

Please, if anyone could give me some advice, I would really appreciate it. Thanks!

Hi Anna

I have to say in all of my time treating clients on Tretinoin I have never experienced this. I am also using 0.5% personally and have had no adverse reactions, only the initial irritation as my skin builds up a resistance. I am wondering if you previously had something going on in the skins deeper layers that it has uncovered, have you ever suffered from cystic acne?

I have researched this and it does appear that others have had this experience so my advise is obviously please stop using this product and you may want to consider fractional or ablative laser resurfacing. This is rather an intense procedure that works to a destroy the epidermis your superficial layer of skin and heats up the dermis, boosting collagen and encouraging regrowth, as the skin reforms new tighter and re-texturised skin will form. I hope this helps Samantha


thanks for your answer to my question and no i have never had a cystic acne before but i am a slow healer.

I am a month of tretinoin and my skin look much better. But is still thin…with broken capilaries and pitted scars caused by tretinoin.

I was so happy at first…but now i so regreat using it.

i don’t know…maybe i have overexfoliated my face all together. I am now using 17.5 snd 20% free Glytone glycolic acid which seems to work on me much better and safer than tretinoin. I badly need to remove the leftover pitts on my face caysed by tretinoin.

Hi Anna

i am glad you are seeing some improvement, in fact the next step i would of recommended would be a series of deep peels in a controlled environment preferably with your dermatologist, however you are on the right track with the at home glycolics. Please don;t forget your sun protection it is so important whilst you are resurfacing! Good luck I do hope everything works out for you. All the best Samantha

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